We are all excited that the results of the Pan-Cancer Analysis of Whole Genomes (PCAWG) are highlighted in a Nature Special (Nature Vol. 578 Issue 7793). Former and current members of the Korbel group were part of this huge initiative.
The PCAWG project, co-led by Jan Korbel, is a collaboration involving more than 1300 scientists and clinicians from 37 countries. It involved analysis of more than 2600 genomes of 38 different tumour types, creating a huge resource of primary cancer genomes.
There is a also summary on EMBLetc.
Recently, Benjamin Raeder, who had been Research Technician and later Lab Officer in Charge with the Korbel group for almost nine years left the group for a new position. We wish him all the best for his new endeavours!
At the same time, we had four people joining the group – check out the people section – Ahmad is a new predoctoral fellow with us, Bernardo and Shimin joined us as computational postdoctoral fellows, and Lucca is supporting our research as an intern for the next months! Also, we get support by Catherine, our new research technician. Welcome!
Check out our new publication in Nature Biotechnologies on scTRIP for single-cell tri-channel processing, a computational framework that integrates read depth, template strand and haplotype phase to comprehensively discover SVs in individual cells.
We are very happy to announce that Tania, who is performing studies for her medical doctor in our lab, collaborating with Prof. Andreas Kulozik’s group at the University clinics, Heidelberg, was recently awarded the Junior Career Fellowship (JCF) of the Heidelberg Research Center for Molecular Medicine (HRCMM). Her work will be part of the MMPU group Molecular Pediatric Oncology (led by Jan Korbel and Andreas Kulozik). Congratulations!
Together with Stefan Pfister (University clinics Heidelberg), Jan Korbel is receiving the Heidelberg Molecular Life Science (HMLS) Award 2018 – congratulations! The award honors internationally recognized achievements of his scientific research in life sciences and acknowledges not only recent scientific breakthroughs but also his effort in mentoring young scientists and success in initiating new research activities. The award ceremony will take place on December 12th at 5pm and you can find more information here. Congratulations, Jan!
Ianthe van Belzen is the latest addition to the Korbel group: coming from Utrecht, the Netherlands, she is doing a research internship with us as part of her Molecular Cellular Life Science master working together with Busra and Tobias. Find out more here.
October was “busy” for the group as we welcome four new group members: Patrick Hasenfeld joined the group at the beginning of October as a new Research Technician. He was followed by our two new PhD student who will be busy with the Predoc course in the upcoming weeks, Maja Starostecka and Wolfram Höps. Finally, Tania Christiansen joined last week and will do an internship with us for the next months. Check out the people section for details!
There is a very recent publication in collaboration with Tobias Marschall and his group at the MPI in Saarbrücken in Bioinformatics on a new algorithm called SaaRclust for de novo assembly. SaaRclust aligns single-cell Strand-seq data directly onto long reads to perform an in silico separation of the data into chromosomes prior to assembly. By using the directionality of Strand-seq they clustered long sequencing reads by chromosomal origin and haplotype.
We are very pleased to announce that Jan received the 2018 Pezcoller Foundation – EACR Cancer Research Award today at the EACR25 Congress in Amsterdam. This prestigious award is presented biennially to recognize the awardee’s scientific excellence in cancer research.
The Korbel group spent three days packed with science (and sun) at Lago di Como in May 2018!